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SUMMARY:Duckweed as a platform for oral vaccines in sustainable fish aquac
 ulture
DTSTART;VALUE=DATE-TIME:20261002T063000Z
DTEND;VALUE=DATE-TIME:20261002T064500Z
DTSTAMP;VALUE=DATE-TIME:20260915T211948Z
UID:indico-contribution-2935@cern.ch
DESCRIPTION:Speakers: Olena Kishchenko (Leibniz Institute of Plant Genetic
 s and Crop Plant Research (IPK) Germany\; Institute of Cell Biology and Ge
 netic Engineering\, National Academy of Science of Ukraine)\nVaccination i
 s a cornerstone of modern health management. It`s particular important in 
 intensive animal production systems\, such as aquaculture\, where high sto
 cking densities facilitate the rapid spread of pathogens. Oral vaccines of
 fer a stress-free\, scalable alternative to traditional fish injections. O
 ur study explores duckweed as platform for vaccine production and as vehic
 le for oral administration. Using a deconstructed potato virus X-based tra
 nsient expression system [1]\, recombinant proteins analogs of antigens of
  koi herpesvirus (KHV) and carp edema virus (CEV) were expressed in duckwe
 ed. Freeze-drying was shown to preserve the recombinant antigens in the du
 ckweed biomass\, enabling long-term storage at room temperature. Obtained 
 freeze-drying duckweed biomass expressing KHV antigens was used for carp i
 mmunization via intraperitoneal injection and intubation [2]. Both methods
  of administration induced release of the specific KHV-neutralising antibo
 dies. Such data provide a strong support for the efficacy of duckweed as p
 roducer of oral vaccines. Transient expression of recombinant proteins in 
 duckweed can facilitate and accelerate the development of oral vaccines fo
 r animals.\n\nhttps://indico.unina.it/event/117/contributions/2935/
LOCATION:Department of Agricultural Sciences of the University of Napoli F
 ederico II\, Portici\, Italy Sala Cinese
URL:https://indico.unina.it/event/117/contributions/2935/
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