28 February 2022
Centro Congressi Partenope
Europe/Rome timezone

Insights on Gastric Cancer: applied bioinformatics approaches

28 Feb 2022, 13:10
Aula Magna (Centro Congressi Partenope)

Aula Magna

Centro Congressi Partenope

Via Partenope, 36 - Napoli


Dr. Pietro Zoppoli (DMMBM - Federico II)


Gastric cancer (GC) remains one of the major causes of cancer-related mortality worldwide. Molecular heterogeneity is a major determinant for the clinical outcomes and an exhaustive tumor classification is currently missing. Histologically normal tissue adjacent to the tumor (NAT) is commonly used as a control in cancer studies, nevertheless shows unique characteristics in several tumor types, possibly leading to suboptimal tumor features definition. Moreover, several limitations to the success of current therapeutic GC treatments may be due to cancer drug resistance that leads to tumor recurrence and metastasis. Apoptosis evasion represents a causative factor for treatment failure in GC as in other cancers and intracellular calcium homeostasis regulation has been found to be associated with apoptosis resistance. Finally, although extensive literature was produced to better define Lauren’s classification subgroups, characterizing pathways and actionable candidates in clinical practice are still missing.
Here I’d like to show:

  1. Our efforts to molecularly define the gastric NATs and their
    confounding impact on GC analyses.
  2. The prognostic value for TRPV2 calcium channel expression in GC and its role as potential target for overcoming cisplatin resistance by promoting apoptosis.
  3. The molecular differences, the active subnetworks, the prognostic and
    actionable candidates between Lauren’s Diffuse and the Intestinal


Russi S, Calice G, Ruggieri V, Laurino S, La Rocca F, Amendola E, Lapadula C, Compare D, Nardone G, Musto P, De Felice M, Falco G, Zoppoli P. Gastric Normal Adjacent Mucosa Versus Healthy and Cancer Tissues: Distinctive Transcriptomic Profiles and Biological Features. Cancers (Basel). 2019 Aug 26;11(9):1248. doi: 10.3390/cancers11091248. PMID: 31454993; PMCID: PMC6769942.

Zoppoli P, Calice G, Laurino S, Ruggieri V, La Rocca F, La Torre G, Ciuffi M, Amendola E, De Vita F, Petrillo A, Napolitano G, Falco G, Russi S. TRPV2 Calcium Channel Gene Expression and Outcomes in Gastric Cancer Patients: A Clinically Relevant Association. J Clin Med. 2019 May 11;8(5):662. doi: 10.3390/jcm8050662. PMID: 31083561; PMCID: PMC6572141.

Laurino S, Mazzone P, Ruggieri V, Zoppoli P, Calice G, Lapenta A, Ciuffi M, Ignomirelli O, Vita G, Sgambato A, Russi S, Falco G. Cationic Channel TRPV2 Overexpression Promotes Resistance to Cisplatin-Induced Apoptosis in Gastric Cancer Cells. Front Pharmacol. 2021 Oct 4;12:746628. doi: 10.3389/fphar.2021.746628. PMID: 34671260; PMCID: PMC8521017.

Department DMMBM

Primary author

Dr. Pietro Zoppoli (DMMBM - Federico II)

Presentation Materials

There are no materials yet.
Your browser is out of date!

Update your browser to view this website correctly. Update my browser now