In the nucleus of cells, chromosomes have been discovered to self-organize into a complex spatial architecture that serves vital functional purposes as, for instance, genes have to establish specific physical contacts with their distal DNA regulators to control transcriptional activities. However, how the system self-assembles to shape the folding of our genome and its functions is only poorly...
Within the cell nucleus of eukaryotic organisms, chromosomes are organized in a complex, non-random three-dimensional (3D) spatial structure, which is intimately linked to vital functional purposes. Indeed, a correct folding allows an efficient communication between genes and their distal regulatory elements while, if altered, can cause severe diseases. Here I will discuss how Polymer Physics,...
