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SUMMARY:Maximum Entropy models of populations of cells
DTSTART;VALUE=DATE-TIME:20250610T124500Z
DTEND;VALUE=DATE-TIME:20250610T131500Z
DTSTAMP;VALUE=DATE-TIME:20260521T043219Z
UID:indico-contribution-1533@cern.ch
DESCRIPTION:Speakers: Andrea De Martino (politecnico di torino)\nI will re
 cap our effort to represent populations of cells using Maximum-Entropy mod
 els defined on the space of single-cell metabolic states. At odds with mor
 e conventional optimization-based theories\, these models place the emphas
 is on (a) cell-to-cell variability\, (b) its relationship with fitness\, a
 nd (c) inter-cellular interactions. Advantages\, limitations and challenge
 s will hopefully emerge. I will also discuss the problem of the physical m
 eaning of the ‘metabolic temperature’ of a population\, along with som
 e new directions\, mainly concerning the large-scale metabolic structuring
  of populations.\n\nhttps://indico.unina.it/event/91/contributions/1533/
LOCATION:Hotel Palazzo Alabardieri Sala Caracciolo
URL:https://indico.unina.it/event/91/contributions/1533/
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