BEGIN:VCALENDAR
VERSION:2.0
PRODID:-//CERN//INDICO//EN
BEGIN:VEVENT
SUMMARY:Modelling ecosystems in complex diseases
DTSTART;VALUE=DATE-TIME:20250611T090000Z
DTEND;VALUE=DATE-TIME:20250611T093000Z
DTSTAMP;VALUE=DATE-TIME:20260608T014630Z
UID:indico-contribution-91-1654@cern.ch
DESCRIPTION:Speakers: Francesca Buffa (Bocconi University )\nhttps://indic
 o.unina.it/event/91/contributions/1654/
LOCATION:Hotel Palazzo Alabardieri Sala Caracciolo
URL:https://indico.unina.it/event/91/contributions/1654/
END:VEVENT
BEGIN:VEVENT
SUMMARY:Small-coupling expansion of dynamic cavity equations for stochasti
 c systems on sparse networks
DTSTART;VALUE=DATE-TIME:20250613T093500Z
DTEND;VALUE=DATE-TIME:20250613T094000Z
DTSTAMP;VALUE=DATE-TIME:20260608T014630Z
UID:indico-contribution-91-1653@cern.ch
DESCRIPTION:Speakers: Mattia Tarabolo (Politecnico di Torino - Dipartiment
 o di Scienza Applicata e Tecnologia (DISAT))\nhttps://indico.unina.it/even
 t/91/contributions/1653/
LOCATION:Hotel Palazzo Alabardieri Sala Caracciolo
URL:https://indico.unina.it/event/91/contributions/1653/
END:VEVENT
BEGIN:VEVENT
SUMMARY:A phase diagram for active phase separation
DTSTART;VALUE=DATE-TIME:20250613T093000Z
DTEND;VALUE=DATE-TIME:20250613T093500Z
DTSTAMP;VALUE=DATE-TIME:20260608T014630Z
UID:indico-contribution-91-1652@cern.ch
DESCRIPTION:Speakers: Damiano Andreghetti (Politecnico di Torino)\nhttps:/
 /indico.unina.it/event/91/contributions/1652/
LOCATION:Hotel Palazzo Alabardieri Sala Caracciolo
URL:https://indico.unina.it/event/91/contributions/1652/
END:VEVENT
BEGIN:VEVENT
SUMMARY:Exact Entropy of Tightly Double Folded Ring Polymers allows for Mu
 lti-scale Modeling of Genomes
DTSTART;VALUE=DATE-TIME:20250612T150000Z
DTEND;VALUE=DATE-TIME:20250612T150500Z
DTSTAMP;VALUE=DATE-TIME:20260608T014630Z
UID:indico-contribution-91-1651@cern.ch
DESCRIPTION:Speakers: Pieter Hendrik Willem van der Hoek (Scuola Internazi
 onale Superiore di Studi Avanzati (SISSA))\nhttps://indico.unina.it/event/
 91/contributions/1651/
LOCATION:Hotel Palazzo Alabardieri Sala Caracciolo
URL:https://indico.unina.it/event/91/contributions/1651/
END:VEVENT
BEGIN:VEVENT
SUMMARY:From cooperativity in photosynthetic antenna systems to bio-mimeti
 c sunlight pumped lasers
DTSTART;VALUE=DATE-TIME:20250612T145500Z
DTEND;VALUE=DATE-TIME:20250612T150000Z
DTSTAMP;VALUE=DATE-TIME:20260608T014630Z
UID:indico-contribution-91-1650@cern.ch
DESCRIPTION:Speakers: Alessia Valzelli (Università di Firenze)\nhttps://i
 ndico.unina.it/event/91/contributions/1650/
LOCATION:Hotel Palazzo Alabardieri Sala Caracciolo
URL:https://indico.unina.it/event/91/contributions/1650/
END:VEVENT
BEGIN:VEVENT
SUMMARY:Boosted continuous Wang-Landau Algorithm: A Novel Approach for Sof
 t Matter Sampling
DTSTART;VALUE=DATE-TIME:20250612T104500Z
DTEND;VALUE=DATE-TIME:20250612T105000Z
DTSTAMP;VALUE=DATE-TIME:20260608T014630Z
UID:indico-contribution-91-1649@cern.ch
DESCRIPTION:Speakers: Camilla Spreti (UNITN - TIFPA)\nhttps://indico.unina
 .it/event/91/contributions/1649/
LOCATION:Hotel Palazzo Alabardieri Sala Caracciolo
URL:https://indico.unina.it/event/91/contributions/1649/
END:VEVENT
BEGIN:VEVENT
SUMMARY:Inference of Chromatin Architecture in Sleep-Deprived Neurons
DTSTART;VALUE=DATE-TIME:20250612T104000Z
DTEND;VALUE=DATE-TIME:20250612T104500Z
DTSTAMP;VALUE=DATE-TIME:20260608T014630Z
UID:indico-contribution-91-1648@cern.ch
DESCRIPTION:Speakers: FLORINDA DI PIERNO (INFN)\nhttps://indico.unina.it/e
 vent/91/contributions/1648/
LOCATION:Hotel Palazzo Alabardieri Sala Caracciolo
URL:https://indico.unina.it/event/91/contributions/1648/
END:VEVENT
BEGIN:VEVENT
SUMMARY:Inference of lineage hierarchies and growth mechanisms in cell pop
 ulations without tracking
DTSTART;VALUE=DATE-TIME:20250611T103000Z
DTEND;VALUE=DATE-TIME:20250611T103500Z
DTSTAMP;VALUE=DATE-TIME:20260608T014630Z
UID:indico-contribution-91-1647@cern.ch
DESCRIPTION:Speakers: Andrea Piras (University of Turin)\nhttps://indico.u
 nina.it/event/91/contributions/1647/
LOCATION:Hotel Palazzo Alabardieri Sala Caracciolo
URL:https://indico.unina.it/event/91/contributions/1647/
END:VEVENT
BEGIN:VEVENT
SUMMARY:Integrating experimental feedback improves generative models for b
 iological sequences
DTSTART;VALUE=DATE-TIME:20250611T102500Z
DTEND;VALUE=DATE-TIME:20250611T103000Z
DTSTAMP;VALUE=DATE-TIME:20260608T014630Z
UID:indico-contribution-91-1646@cern.ch
DESCRIPTION:Speakers: Giovanni Peinetti (Sorbonne Université/Politecnico 
 di Torino)\nhttps://indico.unina.it/event/91/contributions/1646/
LOCATION:Hotel Palazzo Alabardieri Sala Caracciolo
URL:https://indico.unina.it/event/91/contributions/1646/
END:VEVENT
BEGIN:VEVENT
SUMMARY:Emergent time scales of epistasis in protein evolution
DTSTART;VALUE=DATE-TIME:20250611T100000Z
DTEND;VALUE=DATE-TIME:20250611T100500Z
DTSTAMP;VALUE=DATE-TIME:20260608T014630Z
UID:indico-contribution-91-1644@cern.ch
DESCRIPTION:Speakers: Leonardo Di Bari (Politecnico di Torino & Sorbonne U
 niversitè)\nhttps://indico.unina.it/event/91/contributions/1644/
LOCATION:Hotel Palazzo Alabardieri Sala Caracciolo
URL:https://indico.unina.it/event/91/contributions/1644/
END:VEVENT
BEGIN:VEVENT
SUMMARY:Theory of polymers in binary solvent solutions
DTSTART;VALUE=DATE-TIME:20250610T152500Z
DTEND;VALUE=DATE-TIME:20250610T153000Z
DTSTAMP;VALUE=DATE-TIME:20260608T014630Z
UID:indico-contribution-91-1643@cern.ch
DESCRIPTION:Speakers: Davide Marcato (SISSA - Scuola Internazionale di Stu
 di Superiori Avanzati)\nhttps://indico.unina.it/event/91/contributions/164
 3/
LOCATION:Hotel Palazzo Alabardieri Sala Caracciolo
URL:https://indico.unina.it/event/91/contributions/1643/
END:VEVENT
BEGIN:VEVENT
SUMMARY:Coarse Grained Simulations of Kinetoplast DNA
DTSTART;VALUE=DATE-TIME:20250610T152000Z
DTEND;VALUE=DATE-TIME:20250610T152500Z
DTSTAMP;VALUE=DATE-TIME:20260608T014630Z
UID:indico-contribution-91-1642@cern.ch
DESCRIPTION:Speakers: Guglielmo Grillo (University of Trento / TIFPA)\nhtt
 ps://indico.unina.it/event/91/contributions/1642/
LOCATION:Hotel Palazzo Alabardieri Sala Caracciolo
URL:https://indico.unina.it/event/91/contributions/1642/
END:VEVENT
BEGIN:VEVENT
SUMMARY:Physical principles of phase-separation action on chromatin loopin
 g associated to pathogenic gene activation
DTSTART;VALUE=DATE-TIME:20250610T151500Z
DTEND;VALUE=DATE-TIME:20250610T152000Z
DTSTAMP;VALUE=DATE-TIME:20260608T014630Z
UID:indico-contribution-91-1641@cern.ch
DESCRIPTION:Speakers: Andrea Fontana (Università di Napoli "Federico II" 
 and INFN Napoli)\nhttps://indico.unina.it/event/91/contributions/1641/
LOCATION:Hotel Palazzo Alabardieri Sala Caracciolo
URL:https://indico.unina.it/event/91/contributions/1641/
END:VEVENT
BEGIN:VEVENT
SUMMARY:A Single-Cell Microfluidic Device for Studying Leukemia Cell Proli
 feration
DTSTART;VALUE=DATE-TIME:20250610T104500Z
DTEND;VALUE=DATE-TIME:20250610T105000Z
DTSTAMP;VALUE=DATE-TIME:20260608T014630Z
UID:indico-contribution-91-1640@cern.ch
DESCRIPTION:Speakers: Simone Scalise (Sapienza University of Rome & Italia
 n Institute of Technology\, Rome)\nhttps://indico.unina.it/event/91/contri
 butions/1640/
LOCATION:Hotel Palazzo Alabardieri Sala Caracciolo
URL:https://indico.unina.it/event/91/contributions/1640/
END:VEVENT
BEGIN:VEVENT
SUMMARY:Diffusion and enzymatic reactions in solutions crowded by branched
  polymers
DTSTART;VALUE=DATE-TIME:20250610T104000Z
DTEND;VALUE=DATE-TIME:20250610T104500Z
DTSTAMP;VALUE=DATE-TIME:20260608T014630Z
UID:indico-contribution-91-1639@cern.ch
DESCRIPTION:Speakers: Giuliano Migliorini (University of Florence\; CNRS\;
  University of Orléans)\nhttps://indico.unina.it/event/91/contributions/1
 639/
LOCATION:Hotel Palazzo Alabardieri Sala Caracciolo
URL:https://indico.unina.it/event/91/contributions/1639/
END:VEVENT
BEGIN:VEVENT
SUMMARY:Inferring Global Exponents in Subsampled Neural Systems
DTSTART;VALUE=DATE-TIME:20250609T152000Z
DTEND;VALUE=DATE-TIME:20250609T152500Z
DTSTAMP;VALUE=DATE-TIME:20260608T014630Z
UID:indico-contribution-91-1638@cern.ch
DESCRIPTION:Speakers: Davide Conte (Università degli Studi della Campania
  "Luigi Vanvitelli")\nhttps://indico.unina.it/event/91/contributions/1638/
LOCATION:Hotel Palazzo Alabardieri Sala Caracciolo
URL:https://indico.unina.it/event/91/contributions/1638/
END:VEVENT
BEGIN:VEVENT
SUMMARY:Mapping Single-Cell Division Fluctuations to Population Dynamics
DTSTART;VALUE=DATE-TIME:20250609T151500Z
DTEND;VALUE=DATE-TIME:20250609T152000Z
DTSTAMP;VALUE=DATE-TIME:20260608T014630Z
UID:indico-contribution-91-1637@cern.ch
DESCRIPTION:Speakers: Domenico Caudo (University of Rome "La Sapienza")\nh
 ttps://indico.unina.it/event/91/contributions/1637/
LOCATION:Hotel Palazzo Alabardieri Sala Caracciolo
URL:https://indico.unina.it/event/91/contributions/1637/
END:VEVENT
BEGIN:VEVENT
SUMMARY:Signal transduction in cells as a non-equilibrium process: The cas
 e of GPCRs and G proteins
DTSTART;VALUE=DATE-TIME:20250613T091000Z
DTEND;VALUE=DATE-TIME:20250613T093000Z
DTSTAMP;VALUE=DATE-TIME:20260608T014630Z
UID:indico-contribution-91-1636@cern.ch
DESCRIPTION:Speakers: Thibault Fillion (University of Florence\, INFN flor
 ence)\nhttps://indico.unina.it/event/91/contributions/1636/
LOCATION:Hotel Palazzo Alabardieri Sala Caracciolo
URL:https://indico.unina.it/event/91/contributions/1636/
END:VEVENT
BEGIN:VEVENT
SUMMARY:Tuning transduction from hidden observables to optimize informatio
 n harvesting
DTSTART;VALUE=DATE-TIME:20250613T085000Z
DTEND;VALUE=DATE-TIME:20250613T091000Z
DTSTAMP;VALUE=DATE-TIME:20260608T014630Z
UID:indico-contribution-91-1635@cern.ch
DESCRIPTION:Speakers: Daniel Maria Busiello (University of Padova)\nhttps:
 //indico.unina.it/event/91/contributions/1635/
LOCATION:Hotel Palazzo Alabardieri Sala Caracciolo
URL:https://indico.unina.it/event/91/contributions/1635/
END:VEVENT
BEGIN:VEVENT
SUMMARY:Eigenstructure of Hi-C contact matrices: a spectral network approa
 ch to generate synthetic data
DTSTART;VALUE=DATE-TIME:20250613T083000Z
DTEND;VALUE=DATE-TIME:20250613T085000Z
DTSTAMP;VALUE=DATE-TIME:20260608T014630Z
UID:indico-contribution-91-1634@cern.ch
DESCRIPTION:Speakers: Alessandra Merlotti (Department of Physics and Astro
 nomy "Augusto Righi")\nhttps://indico.unina.it/event/91/contributions/1634
 /
LOCATION:Hotel Palazzo Alabardieri Sala Caracciolo
URL:https://indico.unina.it/event/91/contributions/1634/
END:VEVENT
BEGIN:VEVENT
SUMMARY:From Pairwise to Community-Level Interactions: Insights from Engin
 eered Bacterial Strains
DTSTART;VALUE=DATE-TIME:20250612T143500Z
DTEND;VALUE=DATE-TIME:20250612T145500Z
DTSTAMP;VALUE=DATE-TIME:20260608T014630Z
UID:indico-contribution-91-1633@cern.ch
DESCRIPTION:Speakers: Tommaso Redaelli (ETH - Zurich)\nhttps://indico.unin
 a.it/event/91/contributions/1633/
LOCATION:Hotel Palazzo Alabardieri Sala Caracciolo
URL:https://indico.unina.it/event/91/contributions/1633/
END:VEVENT
BEGIN:VEVENT
SUMMARY:Inhibitor-induced transitions in pattern formation and their role 
 in morphogenesis robustness
DTSTART;VALUE=DATE-TIME:20250612T141500Z
DTEND;VALUE=DATE-TIME:20250612T143500Z
DTSTAMP;VALUE=DATE-TIME:20260608T014630Z
UID:indico-contribution-91-1631@cern.ch
DESCRIPTION:Speakers: Silvia Grigolon (Laboratoire Jean Perrin\, CNRS & So
 rbonne Université)\nhttps://indico.unina.it/event/91/contributions/1631/
LOCATION:Hotel Palazzo Alabardieri Sala Caracciolo
URL:https://indico.unina.it/event/91/contributions/1631/
END:VEVENT
BEGIN:VEVENT
SUMMARY:Cross-feeding dynamics in microbial communities under different en
 vironmental
DTSTART;VALUE=DATE-TIME:20250612T102000Z
DTEND;VALUE=DATE-TIME:20250612T104000Z
DTSTAMP;VALUE=DATE-TIME:20260608T014630Z
UID:indico-contribution-91-1630@cern.ch
DESCRIPTION:Speakers: Gabriele Micali (IRCCS Humanitas Research Hospital)\
 nhttps://indico.unina.it/event/91/contributions/1630/
LOCATION:Hotel Palazzo Alabardieri Sala Caracciolo
URL:https://indico.unina.it/event/91/contributions/1630/
END:VEVENT
BEGIN:VEVENT
SUMMARY:Calorimetric cooperativity revisited and generalized: the role of 
 intermediate states
DTSTART;VALUE=DATE-TIME:20250612T100000Z
DTEND;VALUE=DATE-TIME:20250612T102000Z
DTSTAMP;VALUE=DATE-TIME:20260608T014630Z
UID:indico-contribution-91-1629@cern.ch
DESCRIPTION:Speakers: Antonio Trovato (University of Padova)\nhttps://indi
 co.unina.it/event/91/contributions/1629/
LOCATION:Hotel Palazzo Alabardieri Sala Caracciolo
URL:https://indico.unina.it/event/91/contributions/1629/
END:VEVENT
BEGIN:VEVENT
SUMMARY:Fluctuations and the limit of predictability in protein evolution
DTSTART;VALUE=DATE-TIME:20250611T100500Z
DTEND;VALUE=DATE-TIME:20250611T102500Z
DTSTAMP;VALUE=DATE-TIME:20260608T014630Z
UID:indico-contribution-91-1628@cern.ch
DESCRIPTION:Speakers: Saverio Rossi (Sapienza università di Roma)\nhttps:
 //indico.unina.it/event/91/contributions/1628/
LOCATION:Hotel Palazzo Alabardieri Sala Caracciolo
URL:https://indico.unina.it/event/91/contributions/1628/
END:VEVENT
BEGIN:VEVENT
SUMMARY:CIRNet: Evaluation of chemical and physical complementarities for 
 a fast neural network-aided identification of protein interfaces
DTSTART;VALUE=DATE-TIME:20250610T145500Z
DTEND;VALUE=DATE-TIME:20250610T151500Z
DTSTAMP;VALUE=DATE-TIME:20260608T014630Z
UID:indico-contribution-91-1627@cern.ch
DESCRIPTION:Speakers: Greta Grassmann (Sapienza Università di Roma)\nhttp
 s://indico.unina.it/event/91/contributions/1627/
LOCATION:Hotel Palazzo Alabardieri Sala Caracciolo
URL:https://indico.unina.it/event/91/contributions/1627/
END:VEVENT
BEGIN:VEVENT
SUMMARY:Characterizing allosteric communication in h-cisPT enzyme through 
 network and transfer entropy analysis
DTSTART;VALUE=DATE-TIME:20250610T143500Z
DTEND;VALUE=DATE-TIME:20250610T145500Z
DTSTAMP;VALUE=DATE-TIME:20260608T014630Z
UID:indico-contribution-91-1626@cern.ch
DESCRIPTION:Speakers: Carlo Guardiani (Sapienza University of Rome)\nhttps
 ://indico.unina.it/event/91/contributions/1626/
LOCATION:Hotel Palazzo Alabardieri Sala Caracciolo
URL:https://indico.unina.it/event/91/contributions/1626/
END:VEVENT
BEGIN:VEVENT
SUMMARY:OxDNA3: A Coarse-Grained DNA Model with Sequence-Specific Curvatur
 e and Elasticity
DTSTART;VALUE=DATE-TIME:20250610T141500Z
DTEND;VALUE=DATE-TIME:20250610T143500Z
DTSTAMP;VALUE=DATE-TIME:20260608T014630Z
UID:indico-contribution-91-1625@cern.ch
DESCRIPTION:Speakers: Andrea Bonato (University of Strathclyde)\nhttps://i
 ndico.unina.it/event/91/contributions/1625/
LOCATION:Hotel Palazzo Alabardieri Sala Caracciolo
URL:https://indico.unina.it/event/91/contributions/1625/
END:VEVENT
BEGIN:VEVENT
SUMMARY:Exploring Protein Conformational Transitions in the Second Timesca
 le through multiscale Molecular Dynamics: the Case of SHP2 Activation
DTSTART;VALUE=DATE-TIME:20250610T102000Z
DTEND;VALUE=DATE-TIME:20250610T104000Z
DTSTAMP;VALUE=DATE-TIME:20260608T014630Z
UID:indico-contribution-91-1624@cern.ch
DESCRIPTION:Speakers: Paolo Calligari (Tor Vergata University of Rome)\nht
 tps://indico.unina.it/event/91/contributions/1624/
LOCATION:Hotel Palazzo Alabardieri Sala Caracciolo
URL:https://indico.unina.it/event/91/contributions/1624/
END:VEVENT
BEGIN:VEVENT
SUMMARY:Mechano-kinetic characterisation of a small ensemble of myosin mot
 ors: a stochastic fitting approach to actin-myosin interaction dynamics
DTSTART;VALUE=DATE-TIME:20250610T100000Z
DTEND;VALUE=DATE-TIME:20250610T102000Z
DTSTAMP;VALUE=DATE-TIME:20260608T014630Z
UID:indico-contribution-91-1623@cern.ch
DESCRIPTION:Speakers: Valentina Buonfiglio (CNR-INO)\nhttps://indico.unina
 .it/event/91/contributions/1623/
LOCATION:Hotel Palazzo Alabardieri Sala Caracciolo
URL:https://indico.unina.it/event/91/contributions/1623/
END:VEVENT
BEGIN:VEVENT
SUMMARY:Single-molecule trajectories of reactants in chemically active con
 densates
DTSTART;VALUE=DATE-TIME:20250609T145500Z
DTEND;VALUE=DATE-TIME:20250609T151500Z
DTSTAMP;VALUE=DATE-TIME:20260608T014630Z
UID:indico-contribution-91-1622@cern.ch
DESCRIPTION:Speakers: Stefano Bo (King's College London)\nhttps://indico.u
 nina.it/event/91/contributions/1622/
LOCATION:Hotel Palazzo Alabardieri Sala Caracciolo
URL:https://indico.unina.it/event/91/contributions/1622/
END:VEVENT
BEGIN:VEVENT
SUMMARY:Anomalous transport properties of an active tracer in a crowded en
 vironment
DTSTART;VALUE=DATE-TIME:20250609T143500Z
DTEND;VALUE=DATE-TIME:20250609T145500Z
DTSTAMP;VALUE=DATE-TIME:20260608T014630Z
UID:indico-contribution-91-1621@cern.ch
DESCRIPTION:Speakers: Alessandro Sarracino (University of Campania "L. Van
 vitelli")\nhttps://indico.unina.it/event/91/contributions/1621/
LOCATION:Hotel Palazzo Alabardieri Sala Caracciolo
URL:https://indico.unina.it/event/91/contributions/1621/
END:VEVENT
BEGIN:VEVENT
SUMMARY:Pulsating active systems: collective behavior\, hydrodynamics and 
 perspectives
DTSTART;VALUE=DATE-TIME:20250609T141500Z
DTEND;VALUE=DATE-TIME:20250609T143500Z
DTSTAMP;VALUE=DATE-TIME:20260608T014630Z
UID:indico-contribution-91-1620@cern.ch
DESCRIPTION:Speakers: Alessandro Manacorda (CNR-ISC)\nhttps://indico.unina
 .it/event/91/contributions/1620/
LOCATION:Hotel Palazzo Alabardieri Sala Caracciolo
URL:https://indico.unina.it/event/91/contributions/1620/
END:VEVENT
BEGIN:VEVENT
SUMMARY:Self-organized molecular sorting
DTSTART;VALUE=DATE-TIME:20250613T073000Z
DTEND;VALUE=DATE-TIME:20250613T080000Z
DTSTAMP;VALUE=DATE-TIME:20260608T014630Z
UID:indico-contribution-91-1548@cern.ch
DESCRIPTION:Speakers: Andrea Gamba (Politecnico di Torino)\nEukaryotic cel
 ls maintain their internal order through a hectic process of sorting and d
 istillation of molecular factors taking place on their lipid membranes. A 
 similar sorting process is implied in the assembly and budding of envelope
 d viruses. We have proposed a theoretical model of the process\, in which 
 molecular sorting emerges from the coupling of phase separation and membra
 ne bending. Localized sorting domains form by phase separation on lipid me
 mbranes and grow by ab- sorbing laterally diffusing molecules. The domains
  induce membrane bending and the nucleation of a lipid vesicle. Since the 
 newly generated vesicle is enriched in the biochemical factors of the engu
 lfed domain\, this results in a natural distillation process. We found tha
 t sorting efficiency is optimal at intermediate values of the aggregation 
 strength\, where the number of sorting domains is minimized and simple sca
 ling laws hold. Experimental data suggest that living systems may have evo
 lved to exploit these optimal conditions. In this context\, a natural para
 meter controlling the efficiency of molecular distillation is the critical
  size of sorting domains. In the experiments\, sorting domains are classif
 ied into unproductive—characterized by short lifetimes and low proba- bi
 lity of extraction—and productive—those that evolve into vesicles that
  are ultimately extracted. This observation is in agreement with the predi
 ctions of classical nucleation theory for subcritical and supercritical ph
 ase separated domains. Simple estimates suggest that a large pool of disti
 nct molecular species can be sorted in parallel without significantly inte
 rfering with each other\, par- ticularly when their homotypic affinities a
 re comparable. However\, the mean time spent by sorted molecules on the me
 mbrane increases with the heterogeneity of the pool. Overall\, these findi
 ngs provide a unifying perspective on molecular sorting in biological memb
 ranes and offer broader insights into cellular organization and viral asse
 mbly.\n\nhttps://indico.unina.it/event/91/contributions/1548/
LOCATION:Hotel Palazzo Alabardieri Sala Caracciolo
URL:https://indico.unina.it/event/91/contributions/1548/
END:VEVENT
BEGIN:VEVENT
SUMMARY:Maximum Entropy models of populations of cells
DTSTART;VALUE=DATE-TIME:20250610T124500Z
DTEND;VALUE=DATE-TIME:20250610T131500Z
DTSTAMP;VALUE=DATE-TIME:20260608T014630Z
UID:indico-contribution-91-1533@cern.ch
DESCRIPTION:Speakers: Andrea De Martino (politecnico di torino)\nI will re
 cap our effort to represent populations of cells using Maximum-Entropy mod
 els defined on the space of single-cell metabolic states. At odds with mor
 e conventional optimization-based theories\, these models place the emphas
 is on (a) cell-to-cell variability\, (b) its relationship with fitness\, a
 nd (c) inter-cellular interactions. Advantages\, limitations and challenge
 s will hopefully emerge. I will also discuss the problem of the physical m
 eaning of the ‘metabolic temperature’ of a population\, along with som
 e new directions\, mainly concerning the large-scale metabolic structuring
  of populations.\n\nhttps://indico.unina.it/event/91/contributions/1533/
LOCATION:Hotel Palazzo Alabardieri Sala Caracciolo
URL:https://indico.unina.it/event/91/contributions/1533/
END:VEVENT
BEGIN:VEVENT
SUMMARY:Molecular Sorting on Fluctuating Membranes
DTSTART;VALUE=DATE-TIME:20250613T080000Z
DTEND;VALUE=DATE-TIME:20250613T083000Z
DTSTAMP;VALUE=DATE-TIME:20260608T014630Z
UID:indico-contribution-91-1547@cern.ch
DESCRIPTION:Speakers: Luca Dall'Asta (Politecnico di Torino)\nMolecular so
 rting is a vital process in eukaryotic cells\, where proteins and other bi
 omolecules are sorted and encapsulated into lipid vesicles for targeted tr
 ansport to specific organelles and sub- cellular locations. Recent studies
  suggest this process is driven by a physical mechanism based on phase sep
 aration\, in which the formation and growth of sorting domains depends pri
 marily on direct intermolecular interactions. On fluctuating biological me
 mbranes\, entropic Casimir-like forces also play a significant role in pro
 moting this molecular distillation process\, particularly in regimes where
  direct interactions are weak. Our findings\, based on a combination of th
 eoretical analysis and numerical simulations\, reveal that Casimir-like fo
 rces enhance sorting by reducing the critical radius for the formation of 
 new sorting domains and facilitating the capture of molecules in these dom
 ains. The relative rigidity of the membrane and domains are identified as 
 key param- eters governing sorting efficiency. These insights provide a de
 eper understanding of the physical principles shaping molecular organizati
 on in biological membranes.\n\nhttps://indico.unina.it/event/91/contributi
 ons/1547/
LOCATION:Hotel Palazzo Alabardieri Sala Caracciolo
URL:https://indico.unina.it/event/91/contributions/1547/
END:VEVENT
BEGIN:VEVENT
SUMMARY:Laws for cellular growth\, and models to frame them
DTSTART;VALUE=DATE-TIME:20250612T131500Z
DTEND;VALUE=DATE-TIME:20250612T134500Z
DTSTAMP;VALUE=DATE-TIME:20260608T014630Z
UID:indico-contribution-91-1546@cern.ch
DESCRIPTION:Speakers: Marco Cosentino Lagomarsino (Department of Physics "
 Aldo Pontremoli"\, University of Milan and Statistical Physics of Cells an
 d Genomes Lab IFOM ETS - The AIRC Institute of Molecular Oncology)\nProlif
 erating cells organize their resources in order to harness nutrients from 
 the environment and grow. Work in bacteria has highlighted how this behavi
 or leads to striking emergent “growth laws” linking growth to cellular
  composition. However\, beyond bacteria\, we still have limited insight on
  the generality of such laws and even in bacteria some of the key mechanis
 tic aspects underlying them are unclear. I will present our efforts toward
 s a flexible and predictive modeling framework integrating different aspec
 ts of biosynthesis and its regulation\, with applications in bacteria\, bu
 dding yeast and mammalian cells.\n\nhttps://indico.unina.it/event/91/contr
 ibutions/1546/
LOCATION:Hotel Palazzo Alabardieri Sala Caracciolo
URL:https://indico.unina.it/event/91/contributions/1546/
END:VEVENT
BEGIN:VEVENT
SUMMARY:he physics of proofreading mechanisms in cellular signal transduct
 ion
DTSTART;VALUE=DATE-TIME:20250612T124500Z
DTEND;VALUE=DATE-TIME:20250612T131500Z
DTSTAMP;VALUE=DATE-TIME:20260608T014630Z
UID:indico-contribution-91-1545@cern.ch
DESCRIPTION:Speakers: Francesco Piazza (Università di Firenze)\nCellular 
 signaling pathways operate as nonequilibrium biochemical networks that tra
 nsduce di- rected chemical or mechanical signals across the cell. These ca
 scades\, initiated for example by ligand binding to membrane receptors\, i
 nvolve multiple biochemical reactions and complex for- mations. Because si
 gnaling pathways rely on branched\, multiplicative processes\, errors can 
 propagate rapidly\, threatening fidelity. For instance\, incorrect molecul
 ar incorporation at any stage can disrupt signal integrity. To counteract 
 this\, cells have evolved proofreading mechanisms that ensure remarkable a
 ccuracy in processes such as DNA replication and enzymatic reactions. Sinc
 e the pioneering work of Hopfield and Ninio in the 1970s\, it has been und
 erstood that ki- netic proofreading (KP) increases fidelity by introducing
  intermediate chemical steps\, powered by nonequilibrium energy sources\, 
 at the cost of slower propagation. Later advances showed that catalytic pr
 oofreading (CP) can accelerate these error-checking steps\, reducing the d
 elay inherent in KP. An alternative approach involves spatial proofreading
 \, where errors are tested over a finite distance via directed diffusive f
 luxes\, instead of delaying in chemical space\, thus achieving high fideli
 ty “at a distance.” This lecture will explore the general physics of p
 roofreading in signal transduction and introduce a thermodynamically consi
 stent model that integrates spatial and chemical proofreading. I will also
  discuss how these principles apply to real biochemical systems\, highligh
 ting potential proof- reading mechanisms in G-protein coupled receptor sig
 naling and multi-protein self-assembly.\n\nhttps://indico.unina.it/event/9
 1/contributions/1545/
LOCATION:Hotel Palazzo Alabardieri Sala Caracciolo
URL:https://indico.unina.it/event/91/contributions/1545/
END:VEVENT
BEGIN:VEVENT
SUMMARY:Looking for marker genes in healthy and cancer tissues.
DTSTART;VALUE=DATE-TIME:20250612T121500Z
DTEND;VALUE=DATE-TIME:20250612T124500Z
DTSTAMP;VALUE=DATE-TIME:20260608T014630Z
UID:indico-contribution-91-1544@cern.ch
DESCRIPTION:Speakers: Michele Caselle (Dipartimento di Fisica\, Universit
 à di Torino)\nMarker genes are genes that have expression profiles able t
 o distinguish the sub-populations of cells present in the data. They are u
 sed to annotate cell types and “understand” their biology. In cancerou
 s tissues they are used to identify cancer subtypes and thus to fine-tune 
 therapies. Complex pathologies (in particular cancer) are characterized by
  strong variability at the molecular level. Each patient has a different w
 ay of developing cancer. A precise tailoring of therapies requires rapid i
 dentification of the particular cancer subtype and of the altered pathways
  of the patient. This is typically done using marker genes which are often
  themselves the targets of the therapy. However marker genes are typically
  selected using clustering algorithms and their choice is strongly influen
 ced by the choice of the algorithm\, with large uncertainties and\, in som
 e cases\, contradictory results. A physicist’s point of view in this gam
 e can greatly improve the quality of the results and enhance their robustn
 ess. In this talk I will discuss a few results obtained in this context in
  our group in the past few years. In particular I will discuss the use of 
 probabilistic models and of algorithms based on a hierarchical version of 
 stochastic block modelling to identify marker genes.\n\nhttps://indico.uni
 na.it/event/91/contributions/1544/
LOCATION:Hotel Palazzo Alabardieri Sala Caracciolo
URL:https://indico.unina.it/event/91/contributions/1544/
END:VEVENT
BEGIN:VEVENT
SUMMARY:Microbial billiards
DTSTART;VALUE=DATE-TIME:20250612T093000Z
DTEND;VALUE=DATE-TIME:20250612T100000Z
DTSTAMP;VALUE=DATE-TIME:20260608T014630Z
UID:indico-contribution-91-1543@cern.ch
DESCRIPTION:Speakers: Roberto  Di Leonardo (DIPARTIMENTO DI FISICA SAPIENZ
 A  Università di Roma)\nUnlike gas molecules at equilibrium\, the spatial
  organization of self-propelled particles can be very sensitive to what ha
 ppens at the boundaries of their container. Understanding the link between
  boundary phenomena and bulk stationary distributions could enable the des
 ign of optimized con- tainer shapes for the geometric control of confined 
 active particles. Here we propose a boundary method based on the flux tran
 sfer formalism typical of radiometry problems\, where surface ele- ments t
 ransmit and receive “rays” of active particles with infinite persisten
 ce length. We demon- strate the power of this boundary method in the case 
 of the swimming microalgae Euglena gracilis trapped in light-defined billi
 ard geometries. Leveraging our boundary method\, we were able to design a 
 stacked multi-stage billiard geometry\, with a connection scheme between s
 ubunits that breaks spatial symmetry and achieves an exponential amplifica
 tion of cell concentration between its two ends. Surprisingly\, the sensit
 ive dependence on boundary geometry observed in closed microbial billiards
  stands in marked contrast to the robust invariance of mean path lengths t
 raced by E.coli bacteria swimming in microfabricated open billiards with f
 rozen internal disorder.\n\nhttps://indico.unina.it/event/91/contributions
 /1543/
LOCATION:Hotel Palazzo Alabardieri Sala Caracciolo
URL:https://indico.unina.it/event/91/contributions/1543/
END:VEVENT
BEGIN:VEVENT
SUMMARY:Reinforcement Learning and animal behavior
DTSTART;VALUE=DATE-TIME:20250612T090000Z
DTEND;VALUE=DATE-TIME:20250612T093000Z
DTSTAMP;VALUE=DATE-TIME:20260608T014630Z
UID:indico-contribution-91-1542@cern.ch
DESCRIPTION:Speakers: Antonio Celani (ICTP)\nI will review some concepts a
 nd applications of Reinforcement Learning to modeling of animal behavior\n
 \nhttps://indico.unina.it/event/91/contributions/1542/
LOCATION:Hotel Palazzo Alabardieri Sala Caracciolo
URL:https://indico.unina.it/event/91/contributions/1542/
END:VEVENT
BEGIN:VEVENT
SUMMARY:Reconceiving microRNAs as post-transcriptional frequency decoders
DTSTART;VALUE=DATE-TIME:20250612T080000Z
DTEND;VALUE=DATE-TIME:20250612T083000Z
DTSTAMP;VALUE=DATE-TIME:20260608T014630Z
UID:indico-contribution-91-1541@cern.ch
DESCRIPTION:Speakers: Carla Bosia (Politecnico di Torino)\nGene regulation
  is a complex web across biological levels\, and its intricacy often compl
 icates pre- cise interventions\, with off-target effects being a major hur
 dle. To transform this\, we here propose a photoactivatable microRNA-based
  circuit that enables unmatched accuracy in gene targeting\, po- tentially
  reducing off-target effects. Our approach leverages the concept of microR
 NAs (miRNAs) as frequency decoders\, interpreting signal frequencies—suc
 h as oscillatory pulses—to regulate vi- tal cellular processes. We’ve 
 recently shown that periodically expressed miRNAs can selectively repress 
 targets within specific frequency ranges\, creating bell-shaped response c
 urves typical of true frequency decoders. Our model highlights the importa
 nce of miRNA-target interaction dy- namics in frequency-dependent repressi
 on\, adding an orthogonal layer of specificity beyond mere sequence pairin
 g. After introducing our theoretical results\, we present a simple yet pow
 erful cir- cuit in which a photoactivatable miRNA\, whose expression can b
 e periodically controlled by light\, enables dynamic gene expression modul
 ation in single cells.\n\nhttps://indico.unina.it/event/91/contributions/1
 541/
LOCATION:Hotel Palazzo Alabardieri Sala Caracciolo
URL:https://indico.unina.it/event/91/contributions/1541/
END:VEVENT
BEGIN:VEVENT
SUMMARY:All-atom Simulations unveil Physiological and Pharmacological Role
  of Protein Folding Intermediates
DTSTART;VALUE=DATE-TIME:20250612T073000Z
DTEND;VALUE=DATE-TIME:20250612T080000Z
DTSTAMP;VALUE=DATE-TIME:20260608T014630Z
UID:indico-contribution-91-1540@cern.ch
DESCRIPTION:Speakers: Pietro Faccioli (Università Milano-Bicocca and INFN
 )\nOver the last decade\, the combined development of accurate time- resol
 ved experimental tech- niques and advanced algorithms for computer simulat
 ions has opened the possibility of investigat- ing biological mechanisms a
 t atomic resolution with physics-based models. In particular\, combi- nati
 on of experimental information and enhanced sampling techniques now allow 
 the reconstruc- tion of the co- translational folding pathways of biologic
 ally relevant proteins\, at an atomic level of resolution. These innovativ
 e computational technologies reveals the existence of non-native metastabl
 e states transiently appearing along the co-transcriptional folding proces
 s of such pro- teins. The lifetime of these intermediates is set by the am
 ino- acid synthesis rate\, hence is in the several second time scale. In t
 his talk\, we review the evidence indicating that these protein fold- ing 
 intermediates play roles in post-translational regulation. We also discuss
  how the information encoded into protein folding pathways is being exploi
 ted in an entirely new generation of drugs capable of promoting the select
 ive degradation of protein targets. \n\n[1] G. Spagnolli et al.\, “Pharm
 acological inactivation of the prion protein by targeting a folding interm
 ediate”\, Communications Biology 4 (1)\, 6223–124 (2021). DOI:10.1038/
 s42003-020-01585-x. [2] E. Biasini and P. Faccioli “Functional\, pathoge
 nic\, and pharmacological role of protein folding pathways”. Proteins. 2
 023\; 1-9.\n\nhttps://indico.unina.it/event/91/contributions/1540/
LOCATION:Hotel Palazzo Alabardieri Sala Caracciolo
URL:https://indico.unina.it/event/91/contributions/1540/
END:VEVENT
BEGIN:VEVENT
SUMMARY:Predicting the structure of enzymes with metal cofactors: The exam
 ple of [FeFe] hydrogenases
DTSTART;VALUE=DATE-TIME:20250612T070000Z
DTEND;VALUE=DATE-TIME:20250612T073000Z
DTSTAMP;VALUE=DATE-TIME:20260608T014630Z
UID:indico-contribution-91-1539@cern.ch
DESCRIPTION:Speakers: Velia Minicozzi (Department of Physics\, University 
 of Roma Tor Vergata and INFN\, Roma\, Italy)\nThe advent of deep learning 
 algorithms for protein folding opened a new era in the ability of pre- dic
 ting and optimizing the function of proteins once the sequence is known. T
 he task is more intricate when cofactors like metal ions or small ligands 
 are essential to functioning. In this case\, the combined use of tradition
 al simulation methods based on interatomic force fields and deep learning 
 predictions is mandatory. We use the example of [FeFe] hydrogenases\, enzy
 mes of uni- cellular algae promising for biotechnology applications to ill
 ustrate this situation. [FeFe] hydroge- nase is an iron–sulfur protein t
 hat catalyses the chemical reduction of protons dissolved in liquid water 
 into molecular hydrogen as a gas. Hydrogen production efficiency and cell 
 sensitivity to dioxygen are important parameters to optimize the industria
 l applications of biological hydro- gen production. Both parameters are re
 lated to the organization of iron–sulfur clusters within protein domains
 . In this work\, we propose possible three- dimensional structures of Chlo
 rella vulgaris 211/11P [FeFe] hydrogenase\, the sequence of which was extr
 acted from the recently pub- lished genome of the given strain. Initial st
 ructural models are built using: (i) the deep learning algorithm AlphaFold
 \; (ii) the homology modeling server SwissModel\; (iii) a manual construct
 ion based on the best known bacterial crystal structure. Missing iron–su
 lfur clusters are included and microsecond-long molecular dynamics of init
 ial structures embedded into the water solution envi- ronment were perform
 ed. Multiple- walkers metadynamics was also used to enhance the sampling o
 f structures encompassing both functional and non-functional organizations
  of iron–sulfur clus- ters. The resulting structural model provided by d
 eep learning is consistent with functional [FeFe] hydrogenase characterize
 d by peculiar interactions between cofactors and the protein matrix.\n\nht
 tps://indico.unina.it/event/91/contributions/1539/
LOCATION:Hotel Palazzo Alabardieri Sala Caracciolo
URL:https://indico.unina.it/event/91/contributions/1539/
END:VEVENT
BEGIN:VEVENT
SUMMARY:Generative modelling for protein evolution and design
DTSTART;VALUE=DATE-TIME:20250611T093000Z
DTEND;VALUE=DATE-TIME:20250611T100000Z
DTSTAMP;VALUE=DATE-TIME:20260608T014630Z
UID:indico-contribution-91-1538@cern.ch
DESCRIPTION:Speakers: Francesco Zamponi (Sapienza Università di Roma)\nPr
 otein fitness landscapes frequently exhibit epistasis\, where the effect o
 f a mutation depends on the genetic context\, i.e.\, the rest of the prote
 in sequence. Epistasis increases landscape complexity\, often resulting in
  multiple fitness peaks. In its simplest form\, known as global epistasis\
 , fitness is modeled as a non-linear function of an underlying additive tr
 ait. In contrast\, more complex epistasis arises from a network of (pairwi
 se or many-body) interactions between residues\, which cannot be removed b
 y a single non-linear transformation. Recent studies have explored how glo
 bal and network epistasis contribute to the emergence of functional bottle
 necks - fitness landscape topologies where two broad high-fitness basins\,
  representing distinct phenotypes\, are separated by a bottleneck that can
  only be crossed via one or a few mutational paths. I will introduce and a
 nalyze a simple model of global epistasis with an additive underlying trai
 t\, and demonstrate that functional bottlenecks arise with high probabilit
 y if the model is properly calibrated. These results underscore the necess
 ity of sufficient heterogeneity in mutational effects for the emergence of
  functional bottlenecks. Moreover\, the model agrees with experimental fin
 dings\, at least in small enough combinatorial mutational spaces.\n\nhttps
 ://indico.unina.it/event/91/contributions/1538/
LOCATION:Hotel Palazzo Alabardieri Sala Caracciolo
URL:https://indico.unina.it/event/91/contributions/1538/
END:VEVENT
BEGIN:VEVENT
SUMMARY:The Laplacian Renormalization Groups (LRG) unveils the structural 
 organization of heterogeneous networks
DTSTART;VALUE=DATE-TIME:20250611T080000Z
DTEND;VALUE=DATE-TIME:20250611T083000Z
DTSTAMP;VALUE=DATE-TIME:20260608T014630Z
UID:indico-contribution-91-1537@cern.ch
DESCRIPTION:Speakers: Andrea Gabrielli (Department of Civil\, Computer Sci
 ence and Aeronautical Technologies Engineering\, University “Roma Tre”
 )\nHeterogeneous and complex networks represent the intertwined interactio
 ns between real-world elements or agents. Determining the multi-scale meso
 scopic organization of clusters and inter- twined structures is still a fu
 ndamental and open problem of complex network theory. By taking advantage 
 of the recent Laplacian Renormalization Group [1-4] approach \, we scrutin
 ize informa- tion diffusion pathways throughout networks to shed further l
 ight on this issue. Based on inter- node communicability\, our definition 
 provides a clear-cut framework for resolving the multi-scale mesh of struc
 tures in complex networks\, disentangling their intrinsic arboreal archite
 cture. As it does not consider any topological null-model assumption\, the
  LRG naturally permits the intro- duction of scale-dependent optimal parti
 tions and determines the existence of a particular class of nodes\, called
  “metastable” nodes\, that switching regions to which they belong at d
 ifferent scales\, are expected to play a central role in the communication
  between them and\, therefore\, in managing macroscopic effects of the who
 le network [5]. \n\n[1] P Villegas\, T Gili\, G Caldarelli\, A Gabrielli\,
  Laplacian renormalization group for heterogeneous networks\, Nature Physi
 cs 19 (3)\, 445-450 (2023) [2] P Villegas\, A Gabrielli\, F Santucci\, G C
 aldarelli\, T Gili\, Laplacian paths in complex networks: Information core
  emerges from entropic transitions\, Physical Review Research 4\, 033196 (
 2022) [3] A. Gabrielli\, D. Garlaschelli\, S. Patil\, M. A. Serrano\, Netw
 ork Renormalization\, https://arxiv.org/abs/2412.12988\, to appear on Natu
 re Review Physics (2025). [4] A. Poggialini\, P. Villegas\, M.A. Munoz\, A
 . Gabrielli\, Networks with Many Structural Scales: A Renormalization Grou
 p Perspective\, Phys. Rev. Lett. 134\, 057401 (2025) [5] P. Villegas\, A. 
 Gabrielli\, A. Poggialini\, T. Gili\, Multi-scale Laplacian community dete
 ction in heterogeneous networks\, Phys. Rev. Res. 7\, 013065 (2025)\n\nhtt
 ps://indico.unina.it/event/91/contributions/1537/
LOCATION:Hotel Palazzo Alabardieri Sala Caracciolo
URL:https://indico.unina.it/event/91/contributions/1537/
END:VEVENT
BEGIN:VEVENT
SUMMARY:Exploring cooperative effects among features in explainable artifi
 cial intelligence
DTSTART;VALUE=DATE-TIME:20250611T073000Z
DTEND;VALUE=DATE-TIME:20250611T080000Z
DTSTAMP;VALUE=DATE-TIME:20260608T014630Z
UID:indico-contribution-91-1536@cern.ch
DESCRIPTION:Speakers: Sebastiano Stramaglia (UNIBA & INFN\, Sezione di Bar
 i)\nLeveraging the large body of work devoted in recent years to describe 
 redundancy and synergy in higher order interactions among random variables
 \, we propose an adaptive version of a well- known metric of feature impor
 tance\, named Leave One Covariate Out (LOCO)\, to disentangle high- order 
 effects involving a given input feature in regression problems. Applicatio
 ns to biological data sets will be described.\n\nhttps://indico.unina.it/e
 vent/91/contributions/1536/
LOCATION:Hotel Palazzo Alabardieri Sala Caracciolo
URL:https://indico.unina.it/event/91/contributions/1536/
END:VEVENT
BEGIN:VEVENT
SUMMARY:The role of criticality in the structure-function relationship in 
 the human brain
DTSTART;VALUE=DATE-TIME:20250611T070000Z
DTEND;VALUE=DATE-TIME:20250611T073000Z
DTSTAMP;VALUE=DATE-TIME:20260608T014630Z
UID:indico-contribution-91-1535@cern.ch
DESCRIPTION:Speakers: Silvia Scarpetta (Dept. of Physics "E.R.Caianiello" 
 University of Salerno Laboratorio di Reti Neurali "Maria Marinaro)\nHealth
 y brains exhibit a rich dynamic repertoire with flexible and diverse spati
 otemporal pattern replays across microscopic and macroscopic scales.We hyp
 othesize that the system must operate near a critical regime for the funct
 ional repertoire to be fully explored\, and flexible dynamics to emerge.To
  test this hypothesis\, we employ a modular Spiking Neuronal Network model
 \, where each group of Leaky Integrate-and-Fire neurons represents a corti
 cal region.A learning rule based on Spike-Timing-Dependent Plasticity (STD
 P) is used to encode patterns of activations that prop- agate between modu
 les.The patterns exploit empirical information on the number of white-matt
 er fibers between regions. The model [1] displays two distinct dynamical r
 egimes: an uncorrelated low-rate state and a strongly correlated state\, m
 arked by a high Order Parameter value (indicating the similarity of sponta
 neous activity with one of stored patterns).These regimes are separated by
  either a first-order or second-order phase transition\, depending on the 
 strength of global inhi- bition and structured connections. When the hyste
 resis loop shrinks\, a continuous phase transi- tion occurs\, and it opens
  up an extended region with high order parameter fluctuations (close a Wid
 om line with maxima of fluctuations).The model predictions are compared wi
 th empirical data from magnetoencephalographic (MEG) recordings in healthy
  adults. We show that the structural- function correlation is maximized wh
 en the model is the extended critical regime.Then\, the Lev- enshtein dist
 ance is used to quantify the similarity between the sequences of region ac
 tivations in neural avalanches from both the empirical data and the model 
 simulations.Notably a similar reper- toire of sequence is observed in synt
 hetic data and MEG\, only when the model operates within the critical exte
 nded regime. \n\n[1]The role of criticality in the structure-function rela
 tionship in the human brain. M.Angiolelli S.Scarpetta et al. Physical Revi
 ew Research 2025\n\nhttps://indico.unina.it/event/91/contributions/1535/
LOCATION:Hotel Palazzo Alabardieri Sala Caracciolo
URL:https://indico.unina.it/event/91/contributions/1535/
END:VEVENT
BEGIN:VEVENT
SUMMARY:Dual Stochastic Resonance Enhances Sexual Communication in Stink B
 ugs Nezara Viridula
DTSTART;VALUE=DATE-TIME:20250610T131500Z
DTEND;VALUE=DATE-TIME:20250610T134500Z
DTSTAMP;VALUE=DATE-TIME:20260608T014630Z
UID:indico-contribution-91-1534@cern.ch
DESCRIPTION:Speakers: Bernardo Spagnolo (Dipartimento di Fisica e Chimica 
 "E. Segrè”\, Group of Interdisciplinary Theoretical Physics\, Universit
 à degli Studi di Palermo\, Palermo\, Stochastic Multistable Systems Labor
 atory\, Lobachevsky University\, Russia)\nStochastic resonance (SR) phenom
 ena provide insight into the behavior of complex biological sys- tems. Fur
 thermore\, a method for characterizing SR-type behavior in excitable syste
 ms with ape- riodic and arbitrary inputs\, such as broadband signals\, has
  been developed and termed aperiodic stochastic resonance (ASR). It was di
 scovered that noise can enhance the response of a sensory neu- ron to a su
 bthreshold aperiodic input signal\, suggesting a functional role for input
  noise in sensory systems. The simple addition of noise enhances a system
 ’s sensitivity\, improving its ability to dis- criminate weak signals. T
 he southern green stink bug\, Nezara viridula (L.)\, is a cosmopolitan and
  highly polyphagous insect prevalent in many tropical and subtropical regi
 ons\, representing one of the most significant pentatomid pests worldwide.
  Acoustic communication during mating is fundamental to this species’ re
 productive behavior and offers a promising avenue for population control t
 hrough traps that emit acoustic signals. In this study\, we demonstrate ho
 w environmental noise can enhance intersexual communication by analyzing b
 ehavior using the source-direction movement (SDM) ratio. Our findings reve
 al that the SDM exhibits a nonmonotonic trend with two distinct maxima\, s
 uggesting the presence of a “double” behavioral stochastic resonance. 
 Fur- thermore\, the external noise intensity values employed in laboratory
  experiments closely match those observed in open-field measurements. Thes
 e results confirm that environmental noise plays a crucial role in the aco
 ustic communication of N. viridula during the mating period.\n\nhttps://in
 dico.unina.it/event/91/contributions/1534/
LOCATION:Hotel Palazzo Alabardieri Sala Caracciolo
URL:https://indico.unina.it/event/91/contributions/1534/
END:VEVENT
BEGIN:VEVENT
SUMMARY:Statistically validated comorbidity networks
DTSTART;VALUE=DATE-TIME:20250610T121500Z
DTEND;VALUE=DATE-TIME:20250610T124500Z
DTSTAMP;VALUE=DATE-TIME:20260608T014630Z
UID:indico-contribution-91-1532@cern.ch
DESCRIPTION:Speakers: Rosario Nunzio Mantegna (Department of Physics and C
 hemistry - Emilio Segrè - University of Palermo)\nWe investigate a large 
 set of electronic health records (EHRs) collected by wellbeing services co
 unty of Soutwest Finland (Varha) [1]. Different diseases have different pr
 evalence in a given population. For this reason\, the observation of a spe
 cific comorbidity in a given patient could be just the result of a random 
 co-occurrence of two unrelated diseases. Therefore a comorbidity net- work
  of diseases obtained from EHR data can in principle mix comorbidity occur
 rences originating either from random or from biological/medical origin. T
 o extract from EHR data information on biologically or medically induced c
 omorbidity we perform the detection of so-called statistically validated n
 etworks [2\,3]. In this approach\, all links of a projected network (PROJ)
  obtained start- ing from a bipartite network (patient-disease) are subjet
  to a statistical test. Each link in the PROJ network of diseases is subje
 cted to a statistical test able to discriminate whether the presence of a 
 link is an indication of comorbidity of unknown origin (i.e. in technical 
 terms compatible with a so-called “null hypothesis”) or as an indicati
 on of potential comorbidity of biological/medical origin. By performing th
 e same statistical test for all diseases’ pairs present in the PROJ netw
 ork we extract what we address as a SVN. The SVN is providing a selection 
 of those comorbidities that cannot be statistically explained only by rand
 om co-occurrence of diseases of different prevalence. \n\n[1] P. Crisafull
 i\, T. Galla\, A. Karlsson\, R.N. Mantegna\, S. Miccichè\, and J. Piilo\,
  Statistically Validated Comorbidity Networks\, manuscript in preparation 
 (2025). [2] M. Tumminello et al. Statistically validated networks in bipar
 tite complex systems. PLoS ONE\, 6(3):e17994\, Mar. 2011. [3] M.-X. Li et 
 al . Statistically validated mobile communication networks: the evolution 
 of motifs in european and chinese data. New Journal of Physics\, 16(8):083
 038\, 2014.\n\nhttps://indico.unina.it/event/91/contributions/1532/
LOCATION:Hotel Palazzo Alabardieri Sala Caracciolo
URL:https://indico.unina.it/event/91/contributions/1532/
END:VEVENT
BEGIN:VEVENT
SUMMARY:Exploring chromosome organization in healthy and pathogenic genome
 s
DTSTART;VALUE=DATE-TIME:20250610T093000Z
DTEND;VALUE=DATE-TIME:20250610T100000Z
DTSTAMP;VALUE=DATE-TIME:20260608T014630Z
UID:indico-contribution-91-1531@cern.ch
DESCRIPTION:Speakers: Andrea Maria Chiariello (Dipartimento di Fisica Etto
 re Pancini\, Università di Napoli Federico II)\nhttps://indico.unina.it/e
 vent/91/contributions/1531/
LOCATION:Hotel Palazzo Alabardieri Sala Caracciolo
URL:https://indico.unina.it/event/91/contributions/1531/
END:VEVENT
BEGIN:VEVENT
SUMMARY:Effective models of chromatin dynamics
DTSTART;VALUE=DATE-TIME:20250610T090000Z
DTEND;VALUE=DATE-TIME:20250610T093000Z
DTSTAMP;VALUE=DATE-TIME:20260608T014630Z
UID:indico-contribution-91-1530@cern.ch
DESCRIPTION:Speakers: Guido Tiana (University of Milano)\nChromatin is a c
 omplex biopolymer of DNA and proteins that not only packages the genetic m
 aterial in the nucleus but also controls gene expression. The interactions
  that stabilise the three-dimensional structure of chromatin are mediated 
 by different proteins\, often through out-of- equilibrium mechanisms. We h
 ave developed some powerful models to describe such interactions by averag
 ing the degrees of freedom of the proteins. In this way\, we can study the
  dynamics of the polymer and obtain information about its diffusion proper
 ties.\n\nhttps://indico.unina.it/event/91/contributions/1530/
LOCATION:Hotel Palazzo Alabardieri Sala Caracciolo
URL:https://indico.unina.it/event/91/contributions/1530/
END:VEVENT
BEGIN:VEVENT
SUMMARY:Unzipping\, Twisting\, and Unknotting: How Nanopore Translocation 
 Reshapes DNA
DTSTART;VALUE=DATE-TIME:20250610T080000Z
DTEND;VALUE=DATE-TIME:20250610T083000Z
DTSTAMP;VALUE=DATE-TIME:20260608T014630Z
UID:indico-contribution-91-1529@cern.ch
DESCRIPTION:Speakers: Cristian Micheletti (SISSA\, Trieste\, Italy)\nPolym
 er translocation — the process of pulling single filamentous molecules t
 hrough narrow pores — has long been studied as an example of out-of-equi
 librium statistical mechanics and for its rel- evance in DNA sequencing an
 d biological processes. However\, the case in which the polymer structure 
 itself is deeply altered by translocation remains largely unexplored. Here
 \, we address this phenomenon in two prototypical cases involving DNA fila
 ments. First\, we discuss DNA unzipping\, where one of the two strands is 
 pulled through a nanopore while the other remains outside. Next\, we exami
 ne the consequences on DNA organization of a recently discovered effect\, 
 namely that the double-helical segment inside the pore is subject to a sol
 vent-induced rotation. The physical implications of the two settings are d
 iscussed for DNA filaments with and without knots.\n\nhttps://indico.unina
 .it/event/91/contributions/1529/
LOCATION:Hotel Palazzo Alabardieri Sala Caracciolo
URL:https://indico.unina.it/event/91/contributions/1529/
END:VEVENT
BEGIN:VEVENT
SUMMARY:Entropy and topological weight of chromatin loop networks
DTSTART;VALUE=DATE-TIME:20250610T073000Z
DTEND;VALUE=DATE-TIME:20250610T080000Z
DTSTAMP;VALUE=DATE-TIME:20260608T014630Z
UID:indico-contribution-91-1528@cern.ch
DESCRIPTION:Speakers: ENZO ORLANDINI (Università di Padova)\nThe 3D foldi
 ng of mammalian DNA (chromatin) is tightly linked to its transcriptional a
 ctivity\, hence its understanding constitutes an important goal in biophys
 ics. In this talk I present a poly- mer physics model to study the 3D fold
 ing of a chromatin segment. We find by simulations that\, out of the sleut
 h of a priori possible topologies\, only a handful are observed\, characte
 rised by an overwhelming predominance of local loops. We rationalise this 
 surprising result by computing analytically the Boltzmann weight of differ
 ent loop networks. Our results lay down some basic rules to understand the
  topological alphabet of chromatin folding in mammalian genomes.\n\nhttps:
 //indico.unina.it/event/91/contributions/1528/
LOCATION:Hotel Palazzo Alabardieri Sala Caracciolo
URL:https://indico.unina.it/event/91/contributions/1528/
END:VEVENT
BEGIN:VEVENT
SUMMARY:Phase transitions in the nucleus of cells
DTSTART;VALUE=DATE-TIME:20250610T070000Z
DTEND;VALUE=DATE-TIME:20250610T073000Z
DTSTAMP;VALUE=DATE-TIME:20260608T014630Z
UID:indico-contribution-91-1527@cern.ch
DESCRIPTION:Speakers: MARIO NICODEMI (Università di Napoli "Federico II")
 \nhttps://indico.unina.it/event/91/contributions/1527/
LOCATION:Hotel Palazzo Alabardieri Sala Caracciolo
URL:https://indico.unina.it/event/91/contributions/1527/
END:VEVENT
BEGIN:VEVENT
SUMMARY:Orientational Order in Biological Development – Superfluid Shrim
 p
DTSTART;VALUE=DATE-TIME:20250609T124500Z
DTEND;VALUE=DATE-TIME:20250609T131500Z
DTSTAMP;VALUE=DATE-TIME:20260608T014630Z
UID:indico-contribution-91-1524@cern.ch
DESCRIPTION:Speakers: Mark Bowick (Kavli Institute for Theoretical Physics
  UCSB)\nMorphogenesis\, the process through which genes generate form\, es
 tablishes tissue scale order as a template for constructing the complex sh
 apes of the body plan. The extensive growth required to build these ordere
 d substrates is fueled by cell proliferation\, which\, naively\, should di
 srupt order. Understanding how active morphogenetic mechanisms couple cell
 ular and mechanical processes to generate order remains an outstanding que
 stion in animal development. I will review the sta- tistical mechanics of 
 orientational order and discuss the observation of a fourfold orientationa
 lly ordered phase (tetratic) in the model organism Parhyale hawaiensis. I 
 will also discuss theoretical mechanisms for the formation of orientationa
 l order that require both motility and cell division\, with support from s
 elf-propelled vertex models of tissue. The aim is to uncover a robust\, ac
 tive mechanism for generating global orientational order in a non-equilibr
 ium system that then sets the stage for the development of shape and form.
 \n\nhttps://indico.unina.it/event/91/contributions/1524/
LOCATION:Hotel Palazzo Alabardieri Sala Caracciolo
URL:https://indico.unina.it/event/91/contributions/1524/
END:VEVENT
BEGIN:VEVENT
SUMMARY:Daydreaming Hopfield Networks and their surprising effectiveness o
 n correlated data
DTSTART;VALUE=DATE-TIME:20250609T131500Z
DTEND;VALUE=DATE-TIME:20250609T134500Z
DTSTAMP;VALUE=DATE-TIME:20260608T014630Z
UID:indico-contribution-91-1525@cern.ch
DESCRIPTION:Speakers: Federico Ricci Tersenghi (Dip. di Fisica\, Sapienza 
 Università di Roma)\nTo improve the storage capacity of the Hopfield mode
 l\, we develop a version of the dreaming al-\ngorithm that perpetually rei
 nforces the patterns to be stored (as in the Hebb rule)\, and erases the\n
 spurious memories (as in dreaming algorithms). For this reason\, we called
  it Daydreaming. Day-\ndreaming is not destructive and it converges asympt
 otically to stationary retrieval maps. When\ntrained on random uncorrelate
 d examples\, the model shows optimal performance in terms of the\nsize of 
 the basins of attraction of stored examples and the quality of reconstruct
 ion. We also train\nthe Daydreaming algorithm on correlated data obtained 
 via the random-features model and argue\nthat it spontaneously exploits th
 e correlations\, thus increasing even further the storage capacity\nand th
 e size of the basins of attraction. Moreover\, the Daydreaming algorithm i
 s also able to stabi-\nlize the features hidden in the data. Finally\, we 
 test Daydreaming on the MNIST dataset and show\nthat it still works surpri
 singly well\, producing attractors that are close to unseen examples and\n
 class prototypes.\n\nhttps://indico.unina.it/event/91/contributions/1525/
LOCATION:Hotel Palazzo Alabardieri Sala Caracciolo
URL:https://indico.unina.it/event/91/contributions/1525/
END:VEVENT
BEGIN:VEVENT
SUMMARY:A simple model of a sequence-reading diffusion: non-self-averaging
  and self-averaging properties
DTSTART;VALUE=DATE-TIME:20250609T121500Z
DTEND;VALUE=DATE-TIME:20250609T124500Z
DTSTAMP;VALUE=DATE-TIME:20260608T014630Z
UID:indico-contribution-91-1523@cern.ch
DESCRIPTION:Speakers: Enzo Marinari (Sapienza Università di Roma)\nMotiva
 ted by a question about the sensitivity of knots’ diffusive motion to th
 e actual sequence of nucleotides placed on a given DNA\, here we study a s
 imple model of a sequence-reading diffu- sion on a stretched chain with a 
 frozen sequence of “letters” A and B\, having different interaction en
 ergies. The chain contains a single distortion - a hernia - which brings t
 he two letters at its bottom together such that they interact. Due to inte
 ractions with the solvent\, the hernia performs a random hopping motion al
 ong the chain with the transition rates dependent on its actual posi- tion
 . Our two focal questions are a) the dependence of various transport prope
 rties on the letters’ interaction energy and b) whether these properties
  are self-averaging with respect to different re- alizations of sequences.
  We show that the current through a finite interval\, the resistance of th
 is interval and the splitting probabilities on this interval lack self-ave
 raging. On the contrary\, the mean first-passage time through a finite int
 erval with N sites and the diffusion coefficient in a pe- riodic chain are
  self-averaging in the limit N going to infinity. Concurrently\, two latte
 r properties exhibit sample-to-sample fluctuations for finite N\, as evide
 nced by numerical simulations.\n\nhttps://indico.unina.it/event/91/contrib
 utions/1523/
LOCATION:Hotel Palazzo Alabardieri Sala Caracciolo
URL:https://indico.unina.it/event/91/contributions/1523/
END:VEVENT
END:VCALENDAR