BEGIN:VCALENDAR VERSION:2.0 PRODID:-//CERN//INDICO//EN BEGIN:VEVENT SUMMARY:A Single-Cell Microfluidic Device for Studying Leukemia Cell Proli feration DTSTART;VALUE=DATE-TIME:20250610T104500Z DTEND;VALUE=DATE-TIME:20250610T105000Z DTSTAMP;VALUE=DATE-TIME:20260521T044401Z UID:indico-contribution-318-1640@cern.ch DESCRIPTION:Speakers: Simone Scalise (Sapienza University of Rome & Italia n Institute of Technology\, Rome)\nhttps://indico.unina.it/event/91/contri butions/1640/ LOCATION:Hotel Palazzo Alabardieri Sala Caracciolo URL:https://indico.unina.it/event/91/contributions/1640/ END:VEVENT BEGIN:VEVENT SUMMARY:Diffusion and enzymatic reactions in solutions crowded by branched polymers DTSTART;VALUE=DATE-TIME:20250610T104000Z DTEND;VALUE=DATE-TIME:20250610T104500Z DTSTAMP;VALUE=DATE-TIME:20260521T044401Z UID:indico-contribution-318-1639@cern.ch DESCRIPTION:Speakers: Giuliano Migliorini (University of Florence\; CNRS\; University of Orléans)\nhttps://indico.unina.it/event/91/contributions/1 639/ LOCATION:Hotel Palazzo Alabardieri Sala Caracciolo URL:https://indico.unina.it/event/91/contributions/1639/ END:VEVENT BEGIN:VEVENT SUMMARY:Exploring Protein Conformational Transitions in the Second Timesca le through multiscale Molecular Dynamics: the Case of SHP2 Activation DTSTART;VALUE=DATE-TIME:20250610T102000Z DTEND;VALUE=DATE-TIME:20250610T104000Z DTSTAMP;VALUE=DATE-TIME:20260521T044401Z UID:indico-contribution-318-1624@cern.ch DESCRIPTION:Speakers: Paolo Calligari (Tor Vergata University of Rome)\nht tps://indico.unina.it/event/91/contributions/1624/ LOCATION:Hotel Palazzo Alabardieri Sala Caracciolo URL:https://indico.unina.it/event/91/contributions/1624/ END:VEVENT BEGIN:VEVENT SUMMARY:Mechano-kinetic characterisation of a small ensemble of myosin mot ors: a stochastic fitting approach to actin-myosin interaction dynamics DTSTART;VALUE=DATE-TIME:20250610T100000Z DTEND;VALUE=DATE-TIME:20250610T102000Z DTSTAMP;VALUE=DATE-TIME:20260521T044401Z UID:indico-contribution-318-1623@cern.ch DESCRIPTION:Speakers: Valentina Buonfiglio (CNR-INO)\nhttps://indico.unina .it/event/91/contributions/1623/ LOCATION:Hotel Palazzo Alabardieri Sala Caracciolo URL:https://indico.unina.it/event/91/contributions/1623/ END:VEVENT BEGIN:VEVENT SUMMARY:Exploring chromosome organization in healthy and pathogenic genome s DTSTART;VALUE=DATE-TIME:20250610T093000Z DTEND;VALUE=DATE-TIME:20250610T100000Z DTSTAMP;VALUE=DATE-TIME:20260521T044401Z UID:indico-contribution-318-1531@cern.ch DESCRIPTION:Speakers: Andrea Maria Chiariello (Dipartimento di Fisica Etto re Pancini\, Università di Napoli Federico II)\nhttps://indico.unina.it/e vent/91/contributions/1531/ LOCATION:Hotel Palazzo Alabardieri Sala Caracciolo URL:https://indico.unina.it/event/91/contributions/1531/ END:VEVENT BEGIN:VEVENT SUMMARY:Effective models of chromatin dynamics DTSTART;VALUE=DATE-TIME:20250610T090000Z DTEND;VALUE=DATE-TIME:20250610T093000Z DTSTAMP;VALUE=DATE-TIME:20260521T044401Z UID:indico-contribution-318-1530@cern.ch DESCRIPTION:Speakers: Guido Tiana (University of Milano)\nChromatin is a c omplex biopolymer of DNA and proteins that not only packages the genetic m aterial in the nucleus but also controls gene expression. The interactions that stabilise the three-dimensional structure of chromatin are mediated by different proteins\, often through out-of- equilibrium mechanisms. We h ave developed some powerful models to describe such interactions by averag ing the degrees of freedom of the proteins. In this way\, we can study the dynamics of the polymer and obtain information about its diffusion proper ties.\n\nhttps://indico.unina.it/event/91/contributions/1530/ LOCATION:Hotel Palazzo Alabardieri Sala Caracciolo URL:https://indico.unina.it/event/91/contributions/1530/ END:VEVENT BEGIN:VEVENT SUMMARY:Unzipping\, Twisting\, and Unknotting: How Nanopore Translocation Reshapes DNA DTSTART;VALUE=DATE-TIME:20250610T080000Z DTEND;VALUE=DATE-TIME:20250610T083000Z DTSTAMP;VALUE=DATE-TIME:20260521T044401Z UID:indico-contribution-318-1529@cern.ch DESCRIPTION:Speakers: Cristian Micheletti (SISSA\, Trieste\, Italy)\nPolym er translocation — the process of pulling single filamentous molecules t hrough narrow pores — has long been studied as an example of out-of-equi librium statistical mechanics and for its rel- evance in DNA sequencing an d biological processes. However\, the case in which the polymer structure itself is deeply altered by translocation remains largely unexplored. Here \, we address this phenomenon in two prototypical cases involving DNA fila ments. First\, we discuss DNA unzipping\, where one of the two strands is pulled through a nanopore while the other remains outside. Next\, we exami ne the consequences on DNA organization of a recently discovered effect\, namely that the double-helical segment inside the pore is subject to a sol vent-induced rotation. The physical implications of the two settings are d iscussed for DNA filaments with and without knots.\n\nhttps://indico.unina .it/event/91/contributions/1529/ LOCATION:Hotel Palazzo Alabardieri Sala Caracciolo URL:https://indico.unina.it/event/91/contributions/1529/ END:VEVENT BEGIN:VEVENT SUMMARY:Entropy and topological weight of chromatin loop networks DTSTART;VALUE=DATE-TIME:20250610T073000Z DTEND;VALUE=DATE-TIME:20250610T080000Z DTSTAMP;VALUE=DATE-TIME:20260521T044401Z UID:indico-contribution-318-1528@cern.ch DESCRIPTION:Speakers: ENZO ORLANDINI (Università di Padova)\nThe 3D foldi ng of mammalian DNA (chromatin) is tightly linked to its transcriptional a ctivity\, hence its understanding constitutes an important goal in biophys ics. In this talk I present a poly- mer physics model to study the 3D fold ing of a chromatin segment. We find by simulations that\, out of the sleut h of a priori possible topologies\, only a handful are observed\, characte rised by an overwhelming predominance of local loops. We rationalise this surprising result by computing analytically the Boltzmann weight of differ ent loop networks. Our results lay down some basic rules to understand the topological alphabet of chromatin folding in mammalian genomes.\n\nhttps: //indico.unina.it/event/91/contributions/1528/ LOCATION:Hotel Palazzo Alabardieri Sala Caracciolo URL:https://indico.unina.it/event/91/contributions/1528/ END:VEVENT BEGIN:VEVENT SUMMARY:Phase transitions in the nucleus of cells DTSTART;VALUE=DATE-TIME:20250610T070000Z DTEND;VALUE=DATE-TIME:20250610T073000Z DTSTAMP;VALUE=DATE-TIME:20260521T044401Z UID:indico-contribution-318-1527@cern.ch DESCRIPTION:Speakers: MARIO NICODEMI (Università di Napoli "Federico II") \nhttps://indico.unina.it/event/91/contributions/1527/ LOCATION:Hotel Palazzo Alabardieri Sala Caracciolo URL:https://indico.unina.it/event/91/contributions/1527/ END:VEVENT END:VCALENDAR