BEGIN:VCALENDAR VERSION:2.0 PRODID:-//CERN//INDICO//EN BEGIN:VEVENT SUMMARY:Exact Entropy of Tightly Double Folded Ring Polymers allows for Mu lti-scale Modeling of Genomes DTSTART;VALUE=DATE-TIME:20250612T150000Z DTEND;VALUE=DATE-TIME:20250612T150500Z DTSTAMP;VALUE=DATE-TIME:20260410T192310Z UID:indico-contribution-323-1651@cern.ch DESCRIPTION:Speakers: Pieter Hendrik Willem van der Hoek (Scuola Internazi onale Superiore di Studi Avanzati (SISSA))\nhttps://indico.unina.it/event/ 91/contributions/1651/ LOCATION:Hotel Palazzo Alabardieri Sala Caracciolo URL:https://indico.unina.it/event/91/contributions/1651/ END:VEVENT BEGIN:VEVENT SUMMARY:From cooperativity in photosynthetic antenna systems to bio-mimeti c sunlight pumped lasers DTSTART;VALUE=DATE-TIME:20250612T145500Z DTEND;VALUE=DATE-TIME:20250612T150000Z DTSTAMP;VALUE=DATE-TIME:20260410T192310Z UID:indico-contribution-323-1650@cern.ch DESCRIPTION:Speakers: Alessia Valzelli (Università di Firenze)\nhttps://i ndico.unina.it/event/91/contributions/1650/ LOCATION:Hotel Palazzo Alabardieri Sala Caracciolo URL:https://indico.unina.it/event/91/contributions/1650/ END:VEVENT BEGIN:VEVENT SUMMARY:From Pairwise to Community-Level Interactions: Insights from Engin eered Bacterial Strains DTSTART;VALUE=DATE-TIME:20250612T143500Z DTEND;VALUE=DATE-TIME:20250612T145500Z DTSTAMP;VALUE=DATE-TIME:20260410T192310Z UID:indico-contribution-323-1633@cern.ch DESCRIPTION:Speakers: Tommaso Redaelli (ETH - Zurich)\nhttps://indico.unin a.it/event/91/contributions/1633/ LOCATION:Hotel Palazzo Alabardieri Sala Caracciolo URL:https://indico.unina.it/event/91/contributions/1633/ END:VEVENT BEGIN:VEVENT SUMMARY:Inhibitor-induced transitions in pattern formation and their role in morphogenesis robustness DTSTART;VALUE=DATE-TIME:20250612T141500Z DTEND;VALUE=DATE-TIME:20250612T143500Z DTSTAMP;VALUE=DATE-TIME:20260410T192310Z UID:indico-contribution-323-1631@cern.ch DESCRIPTION:Speakers: Silvia Grigolon (Laboratoire Jean Perrin\, CNRS & So rbonne Université)\nhttps://indico.unina.it/event/91/contributions/1631/ LOCATION:Hotel Palazzo Alabardieri Sala Caracciolo URL:https://indico.unina.it/event/91/contributions/1631/ END:VEVENT BEGIN:VEVENT SUMMARY:Laws for cellular growth\, and models to frame them DTSTART;VALUE=DATE-TIME:20250612T131500Z DTEND;VALUE=DATE-TIME:20250612T134500Z DTSTAMP;VALUE=DATE-TIME:20260410T192310Z UID:indico-contribution-323-1546@cern.ch DESCRIPTION:Speakers: Marco Cosentino Lagomarsino (Department of Physics " Aldo Pontremoli"\, University of Milan and Statistical Physics of Cells an d Genomes Lab IFOM ETS - The AIRC Institute of Molecular Oncology)\nProlif erating cells organize their resources in order to harness nutrients from the environment and grow. Work in bacteria has highlighted how this behavi or leads to striking emergent “growth laws” linking growth to cellular composition. However\, beyond bacteria\, we still have limited insight on the generality of such laws and even in bacteria some of the key mechanis tic aspects underlying them are unclear. I will present our efforts toward s a flexible and predictive modeling framework integrating different aspec ts of biosynthesis and its regulation\, with applications in bacteria\, bu dding yeast and mammalian cells.\n\nhttps://indico.unina.it/event/91/contr ibutions/1546/ LOCATION:Hotel Palazzo Alabardieri Sala Caracciolo URL:https://indico.unina.it/event/91/contributions/1546/ END:VEVENT BEGIN:VEVENT SUMMARY:he physics of proofreading mechanisms in cellular signal transduct ion DTSTART;VALUE=DATE-TIME:20250612T124500Z DTEND;VALUE=DATE-TIME:20250612T131500Z DTSTAMP;VALUE=DATE-TIME:20260410T192310Z UID:indico-contribution-323-1545@cern.ch DESCRIPTION:Speakers: Francesco Piazza (Università di Firenze)\nCellular signaling pathways operate as nonequilibrium biochemical networks that tra nsduce di- rected chemical or mechanical signals across the cell. These ca scades\, initiated for example by ligand binding to membrane receptors\, i nvolve multiple biochemical reactions and complex for- mations. Because si gnaling pathways rely on branched\, multiplicative processes\, errors can propagate rapidly\, threatening fidelity. For instance\, incorrect molecul ar incorporation at any stage can disrupt signal integrity. To counteract this\, cells have evolved proofreading mechanisms that ensure remarkable a ccuracy in processes such as DNA replication and enzymatic reactions. Sinc e the pioneering work of Hopfield and Ninio in the 1970s\, it has been und erstood that ki- netic proofreading (KP) increases fidelity by introducing intermediate chemical steps\, powered by nonequilibrium energy sources\, at the cost of slower propagation. Later advances showed that catalytic pr oofreading (CP) can accelerate these error-checking steps\, reducing the d elay inherent in KP. An alternative approach involves spatial proofreading \, where errors are tested over a finite distance via directed diffusive f luxes\, instead of delaying in chemical space\, thus achieving high fideli ty “at a distance.” This lecture will explore the general physics of p roofreading in signal transduction and introduce a thermodynamically consi stent model that integrates spatial and chemical proofreading. I will also discuss how these principles apply to real biochemical systems\, highligh ting potential proof- reading mechanisms in G-protein coupled receptor sig naling and multi-protein self-assembly.\n\nhttps://indico.unina.it/event/9 1/contributions/1545/ LOCATION:Hotel Palazzo Alabardieri Sala Caracciolo URL:https://indico.unina.it/event/91/contributions/1545/ END:VEVENT BEGIN:VEVENT SUMMARY:Looking for marker genes in healthy and cancer tissues. DTSTART;VALUE=DATE-TIME:20250612T121500Z DTEND;VALUE=DATE-TIME:20250612T124500Z DTSTAMP;VALUE=DATE-TIME:20260410T192310Z UID:indico-contribution-323-1544@cern.ch DESCRIPTION:Speakers: Michele Caselle (Dipartimento di Fisica\, Universit à di Torino)\nMarker genes are genes that have expression profiles able t o distinguish the sub-populations of cells present in the data. They are u sed to annotate cell types and “understand” their biology. In cancerou s tissues they are used to identify cancer subtypes and thus to fine-tune therapies. Complex pathologies (in particular cancer) are characterized by strong variability at the molecular level. Each patient has a different w ay of developing cancer. A precise tailoring of therapies requires rapid i dentification of the particular cancer subtype and of the altered pathways of the patient. This is typically done using marker genes which are often themselves the targets of the therapy. However marker genes are typically selected using clustering algorithms and their choice is strongly influen ced by the choice of the algorithm\, with large uncertainties and\, in som e cases\, contradictory results. A physicist’s point of view in this gam e can greatly improve the quality of the results and enhance their robustn ess. In this talk I will discuss a few results obtained in this context in our group in the past few years. In particular I will discuss the use of probabilistic models and of algorithms based on a hierarchical version of stochastic block modelling to identify marker genes.\n\nhttps://indico.uni na.it/event/91/contributions/1544/ LOCATION:Hotel Palazzo Alabardieri Sala Caracciolo URL:https://indico.unina.it/event/91/contributions/1544/ END:VEVENT END:VCALENDAR