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VERSION:2.0
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BEGIN:VEVENT
SUMMARY:Small-coupling expansion of dynamic cavity equations for stochasti
 c systems on sparse networks
DTSTART;VALUE=DATE-TIME:20250613T093500Z
DTEND;VALUE=DATE-TIME:20250613T094000Z
DTSTAMP;VALUE=DATE-TIME:20260410T202840Z
UID:indico-contribution-324-1653@cern.ch
DESCRIPTION:Speakers: Mattia Tarabolo (Politecnico di Torino - Dipartiment
 o di Scienza Applicata e Tecnologia (DISAT))\nhttps://indico.unina.it/even
 t/91/contributions/1653/
LOCATION:Hotel Palazzo Alabardieri Sala Caracciolo
URL:https://indico.unina.it/event/91/contributions/1653/
END:VEVENT
BEGIN:VEVENT
SUMMARY:A phase diagram for active phase separation
DTSTART;VALUE=DATE-TIME:20250613T093000Z
DTEND;VALUE=DATE-TIME:20250613T093500Z
DTSTAMP;VALUE=DATE-TIME:20260410T202840Z
UID:indico-contribution-324-1652@cern.ch
DESCRIPTION:Speakers: Damiano Andreghetti (Politecnico di Torino)\nhttps:/
 /indico.unina.it/event/91/contributions/1652/
LOCATION:Hotel Palazzo Alabardieri Sala Caracciolo
URL:https://indico.unina.it/event/91/contributions/1652/
END:VEVENT
BEGIN:VEVENT
SUMMARY:Signal transduction in cells as a non-equilibrium process: The cas
 e of GPCRs and G proteins
DTSTART;VALUE=DATE-TIME:20250613T091000Z
DTEND;VALUE=DATE-TIME:20250613T093000Z
DTSTAMP;VALUE=DATE-TIME:20260410T202840Z
UID:indico-contribution-324-1636@cern.ch
DESCRIPTION:Speakers: Thibault Fillion (University of Florence\, INFN flor
 ence)\nhttps://indico.unina.it/event/91/contributions/1636/
LOCATION:Hotel Palazzo Alabardieri Sala Caracciolo
URL:https://indico.unina.it/event/91/contributions/1636/
END:VEVENT
BEGIN:VEVENT
SUMMARY:Tuning transduction from hidden observables to optimize informatio
 n harvesting
DTSTART;VALUE=DATE-TIME:20250613T085000Z
DTEND;VALUE=DATE-TIME:20250613T091000Z
DTSTAMP;VALUE=DATE-TIME:20260410T202840Z
UID:indico-contribution-324-1635@cern.ch
DESCRIPTION:Speakers: Daniel Maria Busiello (University of Padova)\nhttps:
 //indico.unina.it/event/91/contributions/1635/
LOCATION:Hotel Palazzo Alabardieri Sala Caracciolo
URL:https://indico.unina.it/event/91/contributions/1635/
END:VEVENT
BEGIN:VEVENT
SUMMARY:Eigenstructure of Hi-C contact matrices: a spectral network approa
 ch to generate synthetic data
DTSTART;VALUE=DATE-TIME:20250613T083000Z
DTEND;VALUE=DATE-TIME:20250613T085000Z
DTSTAMP;VALUE=DATE-TIME:20260410T202840Z
UID:indico-contribution-324-1634@cern.ch
DESCRIPTION:Speakers: Alessandra Merlotti (Department of Physics and Astro
 nomy "Augusto Righi")\nhttps://indico.unina.it/event/91/contributions/1634
 /
LOCATION:Hotel Palazzo Alabardieri Sala Caracciolo
URL:https://indico.unina.it/event/91/contributions/1634/
END:VEVENT
BEGIN:VEVENT
SUMMARY:Self-organized molecular sorting
DTSTART;VALUE=DATE-TIME:20250613T073000Z
DTEND;VALUE=DATE-TIME:20250613T080000Z
DTSTAMP;VALUE=DATE-TIME:20260410T202840Z
UID:indico-contribution-324-1548@cern.ch
DESCRIPTION:Speakers: Andrea Gamba (Politecnico di Torino)\nEukaryotic cel
 ls maintain their internal order through a hectic process of sorting and d
 istillation of molecular factors taking place on their lipid membranes. A 
 similar sorting process is implied in the assembly and budding of envelope
 d viruses. We have proposed a theoretical model of the process\, in which 
 molecular sorting emerges from the coupling of phase separation and membra
 ne bending. Localized sorting domains form by phase separation on lipid me
 mbranes and grow by ab- sorbing laterally diffusing molecules. The domains
  induce membrane bending and the nucleation of a lipid vesicle. Since the 
 newly generated vesicle is enriched in the biochemical factors of the engu
 lfed domain\, this results in a natural distillation process. We found tha
 t sorting efficiency is optimal at intermediate values of the aggregation 
 strength\, where the number of sorting domains is minimized and simple sca
 ling laws hold. Experimental data suggest that living systems may have evo
 lved to exploit these optimal conditions. In this context\, a natural para
 meter controlling the efficiency of molecular distillation is the critical
  size of sorting domains. In the experiments\, sorting domains are classif
 ied into unproductive—characterized by short lifetimes and low proba- bi
 lity of extraction—and productive—those that evolve into vesicles that
  are ultimately extracted. This observation is in agreement with the predi
 ctions of classical nucleation theory for subcritical and supercritical ph
 ase separated domains. Simple estimates suggest that a large pool of disti
 nct molecular species can be sorted in parallel without significantly inte
 rfering with each other\, par- ticularly when their homotypic affinities a
 re comparable. However\, the mean time spent by sorted molecules on the me
 mbrane increases with the heterogeneity of the pool. Overall\, these findi
 ngs provide a unifying perspective on molecular sorting in biological memb
 ranes and offer broader insights into cellular organization and viral asse
 mbly.\n\nhttps://indico.unina.it/event/91/contributions/1548/
LOCATION:Hotel Palazzo Alabardieri Sala Caracciolo
URL:https://indico.unina.it/event/91/contributions/1548/
END:VEVENT
BEGIN:VEVENT
SUMMARY:Molecular Sorting on Fluctuating Membranes
DTSTART;VALUE=DATE-TIME:20250613T080000Z
DTEND;VALUE=DATE-TIME:20250613T083000Z
DTSTAMP;VALUE=DATE-TIME:20260410T202840Z
UID:indico-contribution-324-1547@cern.ch
DESCRIPTION:Speakers: Luca Dall'Asta (Politecnico di Torino)\nMolecular so
 rting is a vital process in eukaryotic cells\, where proteins and other bi
 omolecules are sorted and encapsulated into lipid vesicles for targeted tr
 ansport to specific organelles and sub- cellular locations. Recent studies
  suggest this process is driven by a physical mechanism based on phase sep
 aration\, in which the formation and growth of sorting domains depends pri
 marily on direct intermolecular interactions. On fluctuating biological me
 mbranes\, entropic Casimir-like forces also play a significant role in pro
 moting this molecular distillation process\, particularly in regimes where
  direct interactions are weak. Our findings\, based on a combination of th
 eoretical analysis and numerical simulations\, reveal that Casimir-like fo
 rces enhance sorting by reducing the critical radius for the formation of 
 new sorting domains and facilitating the capture of molecules in these dom
 ains. The relative rigidity of the membrane and domains are identified as 
 key param- eters governing sorting efficiency. These insights provide a de
 eper understanding of the physical principles shaping molecular organizati
 on in biological membranes.\n\nhttps://indico.unina.it/event/91/contributi
 ons/1547/
LOCATION:Hotel Palazzo Alabardieri Sala Caracciolo
URL:https://indico.unina.it/event/91/contributions/1547/
END:VEVENT
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