SARS-CoV-2 is able to re-structure chromatin organization and alters the epigenomic landscape of the host genome, though the mechanisms that produce such changes are still poorly understood. Here, we investigate with polymer physics chromatin reorganization of the host genome, in space and time upon SARS-CoV-2 viral infection.
We show that re-structuring of A/B compartments is well explained...
Quick advances in molecular biology have shed light on the three-dimensional structure of DNA in the cell nucleus, exposing its complex, non-random nature, and its connection to gene regulation. Our challenge is to comprehend the mechanics behind such an intricate genomic architecture and how two or more genomic regions may physically connect with one another. Experiments have shown certain...
