Speaker
Prof.
Enzo Orlandini
(Università di Padova)
Description
The 3D folding of mammalian DNA (chromatin) is tightly linked to its transcriptional activity, hence its understanding constitutes an important goal in biophysics. In this talk I present a polymer physics model to study the 3D folding of a chromatin segment. We find by simulations that, out of the sleuth of a priori possible topologies, only a handful are observed, characterised by an overwhelming predominance of local loops. We rationalise this surprising result by computing analytically the Boltzmann weight of different loop networks. Our results lay down some basic rules to understand the topological alphabet of chromatin folding in mammalian genomes.
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Primary authors
Prof.
Enzo Orlandini
(Università di Padova)
Dr.
Davide Marenduzzo
(University of Edinburgh)
Dr.
Andrea Bonato
(University of Strathclyde)
